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Wound Repair and Regeneration, 2015, 23(1): 1-13

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The keystone discovery initiated an era of mitochondrial pathology in PD

Animal Model:Ischemia (pMCAO) rats [4] Dosage:100 g/kg Administration:Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO)

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Hence, increased DA signaling might contribute to mPFC hyperexcitability as reported here and previously reported hyperactive DA neurons in the ventral tegmental area [4, 5]