Introduction Approximately 700,000 US military personnel were deployed for the Gulf War (GW) ( The neurological category for both sets of criteria includes psychiatric symptoms such as anxiety, post-traumatic stress disorder (PTSD), and depression, which are shown at increased rates among GW veterans since the war ended ( Gulf War Illness is hypothesized to be related to neurotoxic exposures during the GW, which may have caused central nervous system (CNS) dysregulation ( Research has demonstrated that each component of the neurotoxic triad, including glutamate excitotoxicity, oxidative stress, and neuroinflammation, have been implicated individually in the underlying pathophysiology of anxiety, PTSD, and depression (45)
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*Correspondence: Alejandro Gonzlez-Candia [email protected] This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
