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Because accumulated DNA damage and impaired repair mechanisms are well-established contributors to many diseases, including cancer, the role of NAD+ in supporting DNA repair and cellular resilience is generally considered supportive of cellular health rather than harmful

Pyroptosis is recognized as a driver of PVR [44]

Redox regulation at the level of the secondary sulfur metabolic pathway While SOT represent the largest protein family among sulfate-assimilating proteins, their biochemical and functional characterization still lags behind and this is also true for the associated regulation mechanisms