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This finding is clinically meaningful because it suggests that the risk may accumulate over time. Given that many individuals use these medications chronically, whether for blood sugar control or for weight loss, the long-term ocular safety of GLP-1 RAs requires further investigation, he continued

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Thus, in a nutshell, it is possible that the initial DNA damage that predisposes melanocytes to malignant transformation and cytogenetic alterations that later promote actual malignant transformation of the initially transformed melanocytes may be driven by dysregulation in melanin biosynthesis and by the increased cellular content of melanin [10]

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Zelniker, T