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There are also important sex differences in multiple IR-related chronic syndromes, such as obesity, diabetes, and cardiovascular disease that should be further explored in connection to LAC levels

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Based on data from the Phase 2 randomised controlled trial published in The New England Journal of Medicine in 2023, the timeline for seeing meaningful results with retatrutide generally follows a predictable pattern, though individual responses vary considerably depending on dose, titration schedule, and personal factors

10.1039/c3fo60630a 164 Quesada-VzquezS.EseberriI.LesF.Prez-MatuteP.Herranz-LpezM.AtgiC.et al (2024)

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It is a question that the team hopes to explore in follow up studies focused specifically on substance use disorder.