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The short half-life of native GLP- 1-based therapy in the circulation (approximately two minutes after intravenous administration and one to five hours after subcutaneous administration) posed a problem during its early development [9]

the viral load, CD4/CD8 ratio and CD4 and CD8 counts remained stable, thus revealing that ALC treatment was not associated with any progression of HIV infection

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Half-life is a laboratory measurement that has limited relevance to the real-world therapeutic application of BPC-157