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We further hypothesized that supplementation with these metabolic cofactors would promote mitochondrial fatty acid uptake and oxidation, and reduce hepatic fat and inflammation, Zeybel said, adding that the underlying mechanism in the pathogenesis of NAFLD is inadequate removal of hepatic fat by fatty acid oxidation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Khatami F., Payab M., Sarvari M., Gilany K., Larijani B., Arjmand B., Tavangar S.M

However, excessive iron leads to the accumulation of reactive oxygen species within cells, disrupting intracellular redox balance, inducing mitophagy, membrane rupture, and lipid peroxidation, which can damage tissues and cells, ultimately resulting in ferroptosis