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It works at the level of the central nervous system, specifically within the brainstem, where it reduces motor signal activity that contributes to involuntary muscle contraction and spasm

Results were presented at the 2024 European Renal Association Congress in Stockholm, Sweden, and published in The New England Journal of Medicine (1)

1 Shanafelt TD, Barton DL, Adjei AA, Loprinzi CL

Pyruvate slows disease progression in a G93A SOD1 mutant transgenic mouse model