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Examples Pioglitazone (Actos) Dosage Initial: 1530 mg once daily Maximum: 45 mg daily Rosiglitazone (Avandia) Dosage Initial: 4 mg daily as a single dose or in two divided doses Maximum: 8 mg daily as a single dose or in two divided doses Possible side effects include: Weight gain Fluid retention (edema), including macular edema Increased risk of heart failure (related to fluid retention) Osteoporosis and bone fracture Possible increased risk of bladder cancer with pioglitazone Alpha-glucosidase inhibitors Primary mechanism(s) of action Inhibition of intestinal -glucosidase and pancreatic -amylase, which reduces carbohydrate absorption

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2021;10(14): e020734

It is 336 Da, so technically under the 500 Da cutoff, but molecular weight is only one factor