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From a structural point of view, the nine interfacial salt bridges (Table 6) constitute a structural electrostatic scaffold (Figure 5) at the binding interface of GLP-1R ECD and semaglutide analogue A747, which consists of three sets of interfacial salt bridges, as designated by three red numbers (1, 2 and 3) within black circles in Figure 5, and also in Figures 1-5 in supplementary file supps.pdf

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For more on oral BPC-157 and its gastric stability, that topic gets its own deep dive