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Notably, a similar phenomenon was observed in neurons from patients with MS, characterized by upregulated STING expression and markedly reduced STIM1 expression, suggesting that STIM1-STING-GPX4 axis-mediated ferroptosis is closely associated with neuronal injury in human MS pathology (Woo et al., 2024)

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The Glia/Neuron Ratio: How It Varies Uniformly Across Brain Structures and Species and What That Means for Brain Physiology and Evolution. Glia 62: 13771391

The highest incidence of nausea and vomiting occurred during dose escalation phases