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These side effects cause protocol abandonment before visible pigmentation develops (which takes 710 days regardless of starting dose)

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Copper uptake is regulated mainly by Ctr1 translocation between the membrane surface and intracellular vesicles on demand, however, the Ctr1 protein has been shown to be degraded more rapidly under conditions of high copper excess [136]

Final thoughts SIBO isnt always easy to spot, especially when symptoms overlap with IBS