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Reverse osmosis water and irradiated food (Picolab Rodent Diet 20, 5053) were supplied

In thiamin-responsive individuals, the supplementation has been proven effective to correct the phenotype without recourse to the BCAA restriction diet

Glutathione exists in reduced (GSH) and oxidized (GSSG) states

GSH protects cells from oxidative stress-induced apoptosis by scavenging H 2 O 2 , and exogenous GSH supplementation enhances cell viability under oxidative conditions 34

Factorial experimental designs with single-compound and combined-compound treatment arms, alongside vehicle controls, allow researchers to statistically distinguish independent compound effects from any combination-specific outcomes on NAD+ pathway and mitochondrial redox endpoints, a standard approach in multi-compound cellular metabolism research.

People with type 1 or type 2 diabetes should also use this supplement with caution, as it may decrease blood sugar levels