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[91] Macrophages during SLE fail to mature their lysosomes and as a result have impaired degradation of internalized apoptotic debris, which results in chronic activation of Toll-like receptors and permeabilization of the phagolysosomal membrane, allowing activation of cytosolic sensors

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doi: 10.1093/ajcn/86.3.823S

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In peptide research, this relationship is often described as a 1+1=3 effect due to the supra-additive nature of the secretagogues