Interestingly, in the context of Wnt/-catenin signaling-dependent liver tumorigenesis, it was suggested that TCF4 might act in concert with the FOXA factors to regulate hepatocellular carcinoma-specific Wnt target gene expression 73
through their diet or through the synthesis
Additionally, if the SHBG does not significantly increase with replacement, this demonstrates the likelihood of a peripheral resistance to thyroid hormones
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