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Among the innate components, innate immune cells, such as macrophages, neutrophils and mast cells, are capable of producing a range of cytokines that regulate bone metabolism in skeletal diseases (Walsh et al., 2018

10.1038/srep28016 74 NomuraY.SylvesterC

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Jan 2021;56:111-117

A phase I, dose-escalation, multi-center study of PFK-158 in patients with advanced solid malignancies explores a first-in-man inhbibitor of glycolysis

The missense variants in GUSB , TM6SF2 , PNPLA3 and TMC4 are associated with expression levels of the corresponding gene ( cis -eQTLs) in various tissues, and the missense variant in TMC4 is also associated with liver expression of MBOAT7