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Eligibility varies by brand: Ozempic and Rybelsus are approved for type 2 diabetes, while Wegovy is approved for weight loss and fatty liver disease
Review these questions with your healthcare provider: Do you have other medical conditions, including problems with your pancreas, kidneys, liver, or stomach, or have a history of diabetic retinopathy (vision problems related to diabetes)
However, DPP-4 inhibitors (such as sitagliptin or linagliptin) should be discontinued when initiating semaglutide, as both drug classes work through incretin pathways, and combined use offers no additional glycemic benefit while potentially increasing adverse effects
Key high-risk characteristics include: A history of prior DKA or ketosis-prone diabetes:Indicates an underlying predisposition to ketogenesis (38)
Doses adjustments are considered every 4 weeks as needed