PMID: 41759663 Diagn Microbiol Infect Dis 2026 Feb;114(2):117181
Informed consent was obtained in accordance with the Declaration of Helsinki
According to the results from in vitro and in vivo studies, tanshinone IIA pretreatment protects the liver from APAP-induced liver injury by activating Nrf2 and increasing the mRNA and protein levels of the Nrf2 target genes glutamate-cysteine ligase catalytic subunit (GCLC), NQO1, and HO-1 (Wang et al., 2016)
The promising effects observed in vitro often require sophisticated formulations (e.g., with piperine, nanoparticles) to be partially translated in humans, raising questions about the efficacy of simple dietary intake or standard extracts (50)
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes
Prohibition depends on administration route and timing