In patients with arthritis, for example, long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) may result in renal impairment, cardiovascular risks, and stomach ulcers
PalmerCRBellingeJWDalgaardFSimMMurrayKConnollyEet al
There are ongoing efforts to reverse the Medicare ban on obesity treatments, including advocacy in favor of the Treat and Reduce Obesity Act of 2023 (TROA), a scaled-back version of which recently passed out of the House Ways and Means Committee
Tolerance to the gastrointestinal side effects builds during the original slow titration and fades when you stop, so clinicians typically restart at a lower dose and titrate back up rather than jumping to the old dose
For tirzepatide, the gastric emptying effect is most pronounced after the first dose and tends to diminish with continued treatment, a phenomenon known as tachyphylaxis
Circulation 146(24):18821894