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Factors that accelerate weight loss include: High baseline insulin levels Significant visceral fat Pre-diabetes or metabolic syndrome Strong response to appetite suppression Factors that slow progress include: Perimenopause or menopause Low testosterone in men Thyroid dysfunction Chronic stress and poor sleep This is why medical monitoring and lab work matter

Saran, R

Methods 7 , 335336 (2010)

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But it could impact your nutrient intake and cause problems if not managed properly

These findings suggest that rather than only acting in a simple paracrine manner to suppress food intake, endogenously released GLP-1 causes stomach dilation via intestinofugal neurons, which in turn is sensed by spinal afferents innervating the stomach and then transmitted to higher centers via the spinal cord as part of a complex neural arc (Fig