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This appears to be largely mediated through improvements in insulin sensitivity and weight loss, which reduce androgen excess and normalise hypothalamic-pituitary signalling

Bolton JL, Dunlap TL, Hajirahimkhan A, et al

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Both hormones are secreted by endocrine cells that are located in the epithelium of the small intestine and are secreted on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic cells

In addition, we also analyzed eleven other candidate mediators ( Supplementary Table 4 )

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