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Almost all patients will have some gastrointestinal side effects during the first week or two of taking the medication, but those symptoms typically resolve over the first two to four weeks and are rarely severe enough to stop therapy

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Examples include alteplase, reteplase, tenecteplase (all recombinant forms of tPA), and the older agents streptokinase and urokinase

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Due to the exhaustion of cellular and extracellular GSH caused by numerous GSH-consuming pathways the severe inflammation and oxidative stress triggered by the viral infection steals GSH from crucial functions like NO-dependent vasodilatation, disallowing the patient of being protected from an inflammation that can become fatal