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Impairment of proinsulin conversion may be another mechanism for TCF7L2 associated diminished GLP-1 efficacy [568]

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They were then washed twice using F-12 with 0.1% BSA or 0.1% casein, 33 mM HEPES, and incubated for 2 h at 37 C

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Doses may be reduced, or cycling strategies may be employed to prevent receptor desensitization and manage long-term costs