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Takahashi M, Ueda S, Misaki H, et al

Additionally, preterm intestinal organoids were treated with the CFTR activator forskolin (10 M) or with CFTR modulators VX-770 (3 M, potentiator) and VX-445 (3 M, corrector) for 7 days

R Clinical genetics resources: PharmGKB (pharmacogenomics knowledge base): pharmgkb.org CPIC (Clinical Pharmacogenetics Implementation Consortium) guidelines for UGT1A1, NAT2, TPMT: cpicpgx.org Conjugation pathway substrates and testing: The Hepatic Detox Profile (caffeine/aspirin/acetaminophen challenge) is the gold standard functional test for Phase I/II conjugation capacity in clinical practice

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Description PT-141 is a synthetic cyclic heptapeptide