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It inhibits the NF-kappaB signaling pathway (a master regulator of inflammatory gene expression inside cells) and the MAPK pathway (another inflammatory signaling cascade), reducing the production of cytokines that damage follicle cells and disrupt normal hair cycling under conditions of chronic scalp inflammation [1]

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Daily dose splitting (e.g., 5 mg twice daily instead of 10 mg once daily) has been tried by some users on theoretical grounds

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