Data availability The study was approved by the Mass General Brigham Institutional Review Board
Table of contents A brief retrospective on GLP-1 In 1932, La Barre and colleagues coined the incretin concept to describe as yet unknown humoral factors released from the intestine that lowered blood glucose in response to a meal
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The equivalent arginine-serine network in Rattus norvegicus OAT1 has been implicated in gating dynamics and the allosteric modulation of OAT1 by chloride 25 , with chloride binding to R466 rOAT1 in the inward-facing conformation stabilising this network