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While semaglutide is not currently listed as causing allodynia in FDA prescribing information, patients with diabetes may already be at risk for nerve pain from their underlying condition

If you are taking B12 supplements and suspect they may be contributing to anxiety, do not abruptly discontinue without medical advice, particularly if you have been diagnosed with deficiency

Mannucci E, Pala L, Ciani S, Bardini G, Pezzatini A, Sposato I, Cremasco F, Ognibene A, Rotella CM

A study involving hypothyroid patients showed that borderline-to-low B12 levels were more frequent in both overt and subclinical hypothyroidism groups compared with controls [95]

As it hasnt been extensively studied in humans, though, no safe dosage has been found to treat specific medical conditions

Remember, effective doesn't mean it should hurt