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Among the drug-induced DNA lesions, abasic (apurinic/apyrimidinic, AP) sites are one of the most common types in cells, and can lead to more deleterious lesions such as DNA strand breaks [4, 5]

Symptoms typically resolve within days to weeks of dose reduction

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Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with other amino acids to rid the body of ammonia, a byproduct of protein metabolism

Hyperuricemia is associated with impaired intestinal permeability in mice

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