gene polymorphisms) can make the effects of TBI even worse for some people (these tend to be the same genetic risk factors for Alzheimers) APOE is a risk for AD with 3 variants (APOE 2, 3, 4) In the brain, cholesterol is made by astrocytes and the APOE transports this to neurons Most people have 2 APOE3 alleles (1 from each parent) 25% of people have 1 allele that is APOE4 APOE4 increases risk of Alzheimers 2-3x , TBI alone also increases risk of AD 2-3x, stroke and other neurodegenerative diseases People with TBI and APOE4 have 10X risk of AD (25% of people) 2% of people have both alleles as APOE4 (from both parents) 2 APOE4 alleles increases your risk of Alzheimers by 10X 65-80% of all Alzheimers disease have at least 1 allele of APOE4 APOE4 limits your ability to repair damage in the brain such as cleaning up amyloid beta plaque by bringing cholesterol and fatty acids to the neuron s and In addition, APOE4 actually causes other damages itself After damage, the brain usually increase APOE, but if you end up with more APOE4 this actually leads to even more damage Find out if you have APOE with 23andme for ($99) FDA recently stopped them from informing you about specific risk factors (but you can use other services to review your raw data including on Foundmyfitness ) The technology has a small chance of error, so you may get a false positive Rhonda does have 1 allele for APOE4 via her father (she is obviously very interested in finding out ways to reduce her risk, but we wish this wasnt the case) Fighters would be smart to get checked for risk (Joe- fighters will resist this and still want to fight, but waiting until you feel the impact, it is way too late sadly) BUT, sleep also helps you get rid of amyloid beta REM sleep pushes Cerebro Spinal Fluid (CSF) into your brain and washes out amyloid beta and other bad stuff ( glymphatic system ) So if you have APOE4, you REALLY need to do more sleep Nutrition is also a huge factor : People who are obese, diabetics, etc
Your body can reassemble these into glutathione, but this is a slow, rate-limited process
Trust your instincts and seek medical evaluation when something doesnt feel right
R., Benson, A
[11] Tirzepatide is a prescription medication approved by the FDA for the treatment of type 2 diabetes (under the brand name Mounjaro) and chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity (under the brand name Zepbound)
PMCID: PMC9565311
