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In two randomized trials with a total of 500 patients, researchers studied the effects of tirzepatide (titrated to 10 mg or 15mg weekly) versus placebo in people with obesity (average body-mass index [BMI], 39 kg/m 2 ) and moderate-to-severe

Melanotan II has Phase I data only (Dorr 1996, Wessells 1998)

Nature 493, 537541

The intra-brain distribution of compounds is generally described by the unbound volume of distribution in the brain (V u,brain , mL/g brain), which can be estimated using an in in vitro brain slice method (87, 99,100,101)

+6 Linda Bluestein, M.D., Thanks for sharing this important info, Dr

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