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Thus, it is well-established that increased ROS and MDA levels, or reduced levels of antioxidants like SOD, GPx, and catalase, signify mitochondrial dysfunction and oxidative stress, which is also associated with cognitive impairment

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Antioxidants (2021) 10:874

Br J Obstet Gynaecol

This partially overlapping two-stage design enabled biomarker discovery and hypothesis generation followed by independent target validation, while reducing cohort and platform-specific effects commonly encountered in clinical metabolomics 4547

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