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Moreover, other histidine residues of the neighboring PrPs can be involved in Cu 2+ anchoring, with an end result of PrP formation of oligomers ( 7 Akkermansia , butyrate, GLP-1, diabetes and obesity In this section, we will describe the role that the gut microbes, particularly Akkermansia muciniphila , play in protecting the host from diabetes and obesity, via the release of a protein that induces the secretion of glucagon-like peptide 1 (GLP-1) from intestinal L-cells ( A muciniphila is a commensal bacterium in the human gut that feeds only on the sulfomucins produced by the colonic goblet cells

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