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However, they can still cause symptoms such as: Rectal bleeding: The most common symptom of internal hemorrhoids is bright red blood on toilet paper or in the toilet after a bowel movement

These systemic effects are uncommon and typically mild

Finally, publication bias cannot be excluded, especially given the increasing clinical interest in GLP-1RAs and the greater likelihood of publishing studies with favorable outcomes

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This paper has been published in Ophthalmology Retina with the following authors: Jawad Muayad, Asad Loya, Zain Hussain, Debora Lee, Muhammad Chauhan, Andrew Lee, Asadolah Movahedan, and Sami S Dahr

VYLEESI is contraindicated in patients with uncontrolled hypertension or known cardiovascular disease