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The tumors tortuous and hyperpermeable vessels [13,14,15,16] and the near absence of functional lymphatic vessels [17, 18] raise the interstitial fluid pressure (IFP) within breast tumors (Table 2)

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Adrenal adenomas are the most prevalent adrenal tumor type and are typically nonfunctional, meaning they do not produce excessive hormones ( 3.4 Adrenal steroidogenesis The pathophysiology of lethal adrenal disorders is heavily influenced by oxidative stress, and mutations in antioxidant defense genes can have a considerable impact on adrenal steroidogenesis