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IFD foci depend on MTs and dynein motors for formation Under high proteostress conditions, ubiquitinated and non-ubiquitinated aggregated proteins in mammalian (and other) cells can be linked to adaptors such as HDA-6/HDAC6, SQST-1/p62, and the HSP-1/Hsc70/BAG3/FTT-2/14-3-3 complex, which connect to dynein motors and move along microtubule tracks to juxtanuclear sites to deposit aggregate cargos 26,27,28 (summary diagram in Fig

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The Phase 2a FRESH study (NCT05639543) is assessing the safety, tolerability, and preliminary efficacy of INT-787 [102]