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For example, taking 680 mg (one capsule of the Pure Encapsulations formula) twice daily between meals is an effective way to maintain steady blood plasma levels without overwhelming the intestinal transporters

Additionally, people with kidney or liver disease, iron or folic acid deficiencies or bone marrow-affecting conditions should consult their doctor before using B12 injections[18]

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It is true that methylfolate and methylcobalamin work together synergistically along the methylation cycle pathway, but that doesnt necessarily mean that if you tolerate methylfolate well youll also need, want or tolerate methylcobalamin well (even if thats what most doctors, nutritionists, etc are currently saying right now)