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and licensed by Lilly, orforglipron opens the door to a new generation of incretin-based therapies more accessible, manufacturable, and globally deployable

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38 As a quality control measure, medication samples were sent for independent potency analysis (Eagle Analytical, Houston, TX, USA) upon receipt, and at 4 and 6 weeks after production

Sensitivity landmark analyses stratified by timeframe of semaglutide initiation Given that semaglutide was initially approved for type 2 diabetes, with initial obesity approval in 2021, it is possible that inclusion of non-diabetic patients could introduce indication bias in the previously described analyses, as non-diabetic patients enrolled before 2021 likely represent off-label use and may differ systematically from those treated after approval

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Please consult your primary care medical provider for management of these conditions