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(15(12)):e50336 doi:10.7759/cureus.50336

NNMT inhibition Selectively blocks the NNMT enzyme the basis for its metabolic research

The blanket point holds: these compounds are sold for laboratory research only, none is an approved drug, and none has an established human dose

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Meta-analyses show cagrilintide has the lowest odds ratios for nausea, vomiting, and diarrhea among incretin-type therapies

Phase Dual escalation 2 Weeks 17-20 Retatrutide 8 mg/week (hold) Cagrilintide 1.0 mg/week Notes Hold reta, raise cag