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In addition, OAT induces proline dehydrogenase (PRODH), leading to mitochondrial ROS production, which further amplifies TGF-1 signaling and tissue fibrosis [71]

Cost-of-goods estimates from compounded semaglutide (when manufacturers faced shortage-driven competition in 2024-2025) showed production costs of $100 to $200 per 30-day supply

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Studies on HUVECs demonstrated that TMAO increased monocyte adhesion, which was partly attributed to upregulation of vascular cell adhesion molecule-1 (VCAM-1) expression by activated protein kinase C (PKC) and p-NF-B (Ma et al., 2017)

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Alscher, R.G