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References Singer M, Deutschman CS, Seymour CW et al (2016) The third international consensus definitions for sepsis and septic shock (Sepsis-3)

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MTHFR variants like C677T can raise homocysteine and increase demand on the folate and B12 methylation pathway, but they do not by themselves cause deficiency

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MMPs 1 and 3 in particular are associated with disc collagen damage 21,30

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