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However, the main concern with oral delivery is bioavailability, or how much of the peptide is absorbed into the bloodstream after digestion

Freezing causes water in the solution to form ice crystals, and those crystals physically tear apart peptide molecules

The September approval was based on data from a Phase 3 clinical trial called JETALS (NCT03548311), in which Rozebalamin significantly slowed ALS disease progression when given alone or in combination with standard ALS treatments

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In obese mice, it triggered dramatic fat loss when paired with diet changes

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