Orlistat group n(%) Orlistat+L-carnitine group n (%) Flatulence 3 (2.4) 4 (3.0) Constipation 1 (0.8) 1 (0.7) Abdominal pain 1 (0.8) 1 (0.7) Fatty/oily evacuation 8 (6.3) 13 (9.8) Increased defecation 6 (4.8) 10 (7.6) Fecal urgency 4 (3.2) 6 (4.5) Malaise 11 (8.7) 15 (11.4) Data are expressed as n or % 1
As a retrospective cohort analysis, it is inherently subject to biases such as selection bias
Its discovery traces back over 150 years to research on glucosuria ( By blocking sodium-glucose cotransporter 2 in the S1 and S2 segments of the proximal tubule, SGLT2i significantly reduce glucose reabsorption, promoting urinary glucose excretion
Tirzepatide and retatrutide (single molecule): A single engineered molecule that hits multiple receptors simplifies the formulation to one compound with one pharmacokinetic profile, and allows the balance of receptor activation to be tuned at the molecular-design level
The Gila monster is not the only reptile to inspire groundbreaking drugs
In recent years, this powerful antioxidant has gained popularity across Koilkata as a sought-after aesthetic treatmentnot just for skin brightening but also for managing chronic skin conditions like atopic dermatitis, eczema, and psoriasis