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Sustained inhibition could have tissue-specific effects that short animal experiments do not fully capture

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Current evidence supports the idea that ammonia is only one component of the numerous pathophysiologic factors that contribute to the appearance of HE.29 The pathophysiologic approach should include the integrity of the natural detoxification sites of the liver, intestine, muscle, kidney, and astrocyte, as well as the study of the collateral circulation (fig

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