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To Issue 172 C itation: Lock D, Rethinking GLP-1 Delivery Devices: Designing for Users Beyond Diabetes
Clinical trials of GLP-1 medications, including the STEP program for semaglutide and SURMOUNT trials for tirzepatide, have documented improvements in physical function scores and quality of life measures
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However, a recent meta-analysis of dual-energy X-ray absorptiometry-acquired body composition outcomes showed that approximately 30 % of the total weight loss achieved with GBT is attributed to lean mass loss [162], and a post hoc analysis of SURMOUNT-1 has reported that approximately 25 % of the weight loss in SURMOUNT-1 was due to lean body mass loss [163], thus suggesting that approximately 1 in 4 kg lost with GBT amounts to lean body mass loss
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