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For example, it plays a pivotal role in regenerating other antioxidants, such as tocopherols and ascorbate [4]

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TLK286 clinical effects were investigated in the last decade in phase II and phase III trials for the treatment of drug-resistant ovarian cancer 112,113

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Although the signaling pathways leading to the progression of apoptosis have been extensively characterized, recent studies highlight the regulatory role of changes in the intracellular milieu (permissive apoptotic environment) in the efficient activation of the cell death machinery