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All quantitative efficacy data (body-weight loss, fat-mass reduction) comes from a single diet-induced-obese mouse study

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Complementary studies have identified RNF11 as another critical mediator of CRC progression, functioning through differential mRNA expression and ubiquitin ligase activity that promote tumor proliferation and immune escape, thereby representing an emerging therapeutic target (36)

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Lower hippocampal volume in patients suffering from depression: a meta-analysis