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While generally well-tolerated, GLP-1 RAs can be associated with adverse events, including pancreatitis, acute kidney injury (AKI), gastroparesis, nausea, diarrhea, abdominal pain, and decreased appetite

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Albeit that this model seems to be a fairly close approach to the true role for inositols as insulin-sensitizers (Figure 2), data on supplementation with inositol derivatives might question whether IPGs are the only way for inositols to modulate insulin signaling

[32] A 2013 international multicentre retrospective cohort study has indeed shown that in patients with heart failure of different etiologies the addition of trimetazidine on conventional optimal therapy can improve mortality and morbidity

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