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They found that an imbalance of SAMe and SAH resulting from these vitamin deficiencies was associated with changes in methylation pattern of PSEN1 and BACE with consequent increases in PS1 and BACE levels, contributing to neurotoxic A deposition [6]

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However, most of these studies lacked rigorous exclusion criteria in the selection of subjects to avoid the influence of confounders

Rev Mal Respir