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Acknowledgements This work was supported by grants from the National multidisciplinary collaborative diagnosis and treatment capacity building project for major diseases (TJZ202104), the Natural Science Foundation of China (82270643, 82070644, 82170621 and 82370645), the Science and Technology Major Program of Sichuan Province (2022ZDZX0019), the Sichuan Science and Technology Program (2024NSFSC0645), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (ZYJC18008, ZYGD22006)

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Neuroscience 167:10441056 Park H, Kam T, Kim Y et al (2012) Neuropathogenic role of adenylate kinase-1 in A-mediated tau phosphorylation via AMPK and GSK3

The pharmacological limitations to treating the overwhelming set of symptoms affecting patients with anxiety and depression have opened avenues to search for natural compounds and nutritional strategies [7]

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Animals and Administered Products Des rats mles Sprague-Dawley EOPS 0F1 (IFFA CREDO, France) ont t utiliss dans cette tude