Structural basis for the activity and substrate specificity of Erwinia chrysanthemi L-asparaginase
An oral version of semaglutide, sold under the brand name Rybelsus, has been on the market since 2019 but is not approved for weight management and isnt as effective for weight loss as injectable GLP-1s
Clinicians should monitor patients for potential adverse effects including pancreatitis (severe, persistent abdominal pain), gallbladder disease (right upper quadrant pain), diabetic retinopathy complications (especially with rapid glucose improvement), acute kidney injury with dehydration, and hypoglycemia when combined with insulin or sulfonylureas
The agency also identified gaps concerning characterisation, impurities, aggregates, pharmacokinetics, toxicology and immunogenicity
Managing Lower GI Issues: Constipation & Bloating The most common complaint on these medications is severe constipation
Guidelines are pretty straightforward if you opt for the oral form of intake which is capsules or the nasal spray version
